Exported Medicines

Corlanor (Ivabradine)

Corlanor (Ivabradine)

General Information

Corlanor (Ivabradine) is used by people with a certain heart problem or chronic heart failure. This helps to prevent it from getting worse and needing treatment in a hospital. Heart failure is a condition where your heart does not pump blood as well as it should.

 

How does Corlanor (Ivabradine) work?

Corlanor (Ivabradine) lowers heart rate by selectively preventing ‘funny channels’ in the heart. It is in a concentration-dependent manner without disturbing any other cardiac ionic channels. This drug binds by attaching and entering to a site on the channel pore from the intracellular side and disrupts the funny channels’ ion current flow. In which it prolongs diastolic depolarization and lowering heart rate. The funny channels’ currents are located in the sinoatrial node and are the home of all cardiac pacemaker activity. Corlanor (Ivabradine) therefore, consequently lowering heart rate, lowers the pacemaker firing rate, and reducing myocardial oxygen demand. This allows for improved oxygen supply and mitigation of ischemia. It also allows for higher exercise capacity and reduction in angina episodes.

 

Why use Corlanor (Ivabradine)?

Corlanor (Ivabradine) is a hyperpolarization-activated cyclic nucleotide-gated channel blocker. This channel is responsible for the cardiac pacemaker If (funny channel) current which regulates heart rate. This is supplied as tablets for oral administration. This is available in the strengths of 5mg and 7.5mg that contain ivabradine as the free base equivalent. The Food and Drug Administration (FDA) approved this treatment.

 

How to use Corlanor (Ivabradine)?

The recommended starting dose for Corlanor (Ivabradine) is 5mg twice a day. The dose should be adjusted based on heart rate after 2 weeks of treatment. The maximum dose is 7.5mg twice a day. You may take it with or without food. Take it regularly or exactly as directed by your doctor.

 

What are the side-effects of Corlanor (Ivabradine)?

  • Dizziness or fainting
  • Chest pain or fainting
  • Worsening shortness of breath
  • Fast, slow, or irregular heartbeat
  • Severe tiredness or weakness
  • Severe or persistent headache
  • Hoarseness
  • Difficulty swallowing or breathing
  • Increased blood pressure

 

Warnings and Precautions

  • Before using this treatment, let your doctor know if you have any medical history, current medications, or any allergies.
  • If you are pregnant or breastfeeding women, consult your doctor first.
  • You should not share this or any of your medications with others who have the same symptoms as yours.
  • Do not twice the prescribed dosage to avoid some complications.
  • Keep this away from the reach of children.