Exported Medicines

Disalcid (Salsalate)

Disalcid (Salsalate)

General Information

Disalcid (Salsalate) is used to relieve pain from various conditions. This reduces swelling, pain, and joint stiffness from arthritis. This may also be used to treat fever and inflammation in the body. Salsalate is converted in the body to salicylic acid which is its active form and closely related to aspirin.

How does Disalcid (Salsalate) work?

Disalcid (Salsalate) is primarily associated with inhibition of prostaglandin synthesis. This inhibition of prostaglandin synthesis is done through the inactivation of cyclooxygenase-1 (COX-1) and COX-2. Those are responsible for catalyzing the formation of prostaglandins in the arachidonic acid pathway. Although salicylic acid which is the primary metabolite of salsalate, is a weak inhibitor of prostaglandin synthesis in vitro. It appears to selectively inhibit prostaglandin synthesis in vivo and provides anti-inflammatory activity equal to aspirin and indomethacin. Unlike aspirin, salsalate does not inhibit platelet aggregation.


Why use Disalcid (Salsalate)?

Disalcid (Salsalate) is known as a nonsteroidal anti-inflammatory drug (NSAID). This is available as a capsule for oral administration that contains 500mg of Salsalate. It also contains gelatin, colloidal silicon dioxide, and magnesium stearate. The Food and Drug Administration (FDA) approved this medication.

How to use Disalcid (Salsalate)?

The usual dosage of Disalcid (Salsalate) is 3000mg a day given in divided doses as:

  • Two doses of two 750mg tablet
  • Two doses of three 500mg tablet
  • Three doses of two 500mg tablet

It is to be taken 2-3 times a day. You may take it with or without food. You should take it by mouth with a full glass of water. Do not lie down for at least 10 minutes after taking this drug. Take at the same time each day. Do not stop or change the dosage without consulting your doctor.


What are the side-effects of Disalcid (Salsalate)?

  • Heartburn
  • Upset stomach
  • Mild dizziness

Call your doctor if these occur:

  • Shortness of breath or severe dizziness
  • Sudden numbness or weakness
  • Bloody, black or tarry stools
  • Easy bruising or bleeding
  • Fever or chills
  • Flu symptoms and sore throat
  • Severe stomach pain or on-going nausea and vomiting
  • Dark urine and jaundice

Warnings and Precautions

  • If you are taking this medication, limit your alcohol beverages and stop smoking.
  • Avoid any activity that needs your alertness. This drug may make you feel dizzy.
  • Tell your doctor if you are allergic to it or if you have any allergies.
  • Inform your doctor if you have any medical history or current treatments.