Ecallantide

What condition does Ecallantide treat?

Ecallantide is used for the treatment of an acute attack called hereditary angioedema (HAE). This medication may lessen the symptoms of this condition like rapid swelling and pain of the feet, hands, face, limbs, tongue, or throat.

HAE is a disorder characterized by recurrent episodes of severe swelling. The most common area of the body to develop is swelling in the face, limbs, airway, and intestinal tract.

Ecallantide is produced by a method known as recombinant DNA technology. It is made by a cell that has received a gene (DNA) which makes the cell able to produce it. This medication is for injection, subcutaneous use. The Food and Drug Administration (FDA) has already approved this medication. 

How does Ecallantide work?

Ecallantide blocks an enzyme in the blood called kallikrein. Kallikrein is a part of a complex network of proteins that has several effects on the body. One of which results in increased levels of a protein called bradykinin. It causes the blood vessels to widen and leak fluid into the surrounding tissue. This leakage of fluids causes the swelling attacks seen in angioedema. By blocking the actions of kallikrein, this drug is expected to help lessen the swelling and related symptoms of angioedema.

What is the recommended dosage for Ecallantide?

This prescription is to be given by your doctor or healthcare professional. This is to be injected under your skin either in the thigh, abdomen, or upper arms. You may receive three shots that are separated by at least 2 inches. An additional three shots may be given in 24 hours. It is if the HAE attack continues. The dosage is based on your medical condition and response.

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not have this medicine in smaller or larger amounts or for longer than recommended. If you missed a dose, it is important to inform your doctor.

What are the side effects of Ecallantide?

  • Stomach
  • Vomiting
  • Fever
  • Diarrhea
  • Nausea
  • Headache
  • Sore throat
  • Tired feeling
  • Injection site reactions (rash, pain, irritation, bruising, itching, or redness)

What are the precautions of taking Ecallantide?

  • Do not receive an injection into the skin that is tender, hard, or red.
  • Inform your doctor if you are allergic to this medication or if you have any allergies.
  • Inform your doctor if your condition gets worse or if it does not improve.
  • This prescription may not be recommended for pregnant women. If you are breastfeeding women, consult your doctor r first.
  • Inform your doctor if you have any medical history.
  • Your doctor must check your progress closely to make sure that this medication is working correctly and to decide if you should continue to receive it.
  • This prescription may not be recommended for use in children younger than 12 years of age. Safety and efficacy have not been established yet.
  • Certain drugs should not be used at or around the time of eating certain types of food since interactions might occur. Using tobacco or alcohol with certain medications may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with tobacco, alcohol, or food.