General Information

Kalydeco (Ivacaftor) is indicated for the treatment of cystic fibrosis. It is in people with an abnormal CFTR gene. CFTR is a chloride channel and membrane protein in vertebrates. It is encoded by the CFTR gene. CFTR means cystic fibrosis transmembrane conductance regulator.

Cystic fibrosis is a progressive and genetic disease that causes persistent lung infection. It limits the ability to breathe over time. This medication may help improve breathing and lessen the risk of lung infections. It will also help improve weight gain.

How does Kalydeco (Ivacaftor) work?

Kalydeco (Ivacaftor) helps increased chloride transport. It is by potentiating the channel-open probability of the G551D-CFTR protein.

Cystic fibrosis is initiated by changes in a gene. In which it converts for the CFTR protein that controls ion and water transport in the body. The defect in chloride and water transport results in the formation of thick mucus. That it builds up in the lungs and digestive tract. That it leads to severe respiratory and digestive problems.

Why use Kalydeco (Ivacaftor)?

Kalydeco (Ivacaftor) is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. The CFTR protein is a chloride channel present at the surface of epithelial cells in multiple organs. This is supplied as tablets for oral use. Each film-coated tablet contains 150 mg of strength. It also has Ivacaftor as an active ingredient. This was approved by the U.S. Food and Drug Administration (FDA).

How to use Kalydeco (Ivacaftor)?

Kalydeco (Ivacaftor) is usually taken twice a day every 12 hours. You may take each dose with fat-containing food such as eggs, cheese, or butter. It is to be taken by mouth with a full glass of water.

The dosage is based on your condition and response. Remember to take it at the same time every day. Do not increase the dose without consulting your doctor.

What are the side-effects of Kalydeco (Ivacaftor)?

Common side effects:

• Headache
• Stomach pain
• Rash
• Nausea
• Diarrhea
• Acne
• Dizziness
• Muscle or joint pain
• Cold symptoms like sneezing, stuffy nose, or sore throat

Warnings and Precautions

• Before using this treatment, inform your doctor if you are allergic to it.
• Tell to your doctor if you have any medical history, current medications, or allergies.
• Do not share this with others who have the same condition as yours.
• This may make you feel dizzy. Avoid using machinery or driving.
• Consult first a doctor if you are pregnant or breastfeeding women.
• Keep this away from the reach of children or pets.