General Information

Mafenide Acetate is used to treat and prevent wound infections in patients with severe burns. This may be used alone or with another medication. Killing bacteria helps to promote wound healing. It also lessens the risk of the bacteria spreading to surrounding skin or to the blood. Therefore, this helps to prevent a serious blood infection called sepsis.

How does Mafenide Acetate work?

Mafenide Acetate is a synthetic sulfonamide antibiotic. This works by killing bacteria that may affect an open wound. This also decreases the bacterial population present in the avascular tissues of burns. Mafenide Acetate permits spontaneous healing of deep partial-thickness burns.  

Why use Mafenide Acetate?

Mafenide Acetate is an antimicrobial agent designated chemically as a-amino-p- toluenesulfonamide monoacetate. This comes as a cream for topical use. This medication contains an active ingredient of Mafenide Acetate. This is provided in packets containing 50 g of sterile Mafenide Acetate. The Food and Drug Administration (FDA) has already approved this prescription.

How to use Mafenide Acetate?

The recommended dosage is based on your medical condition and response. Do not take more or less than it is given by your doctor. This medication is to be used on the skin only.

Wash your hands before and after using this medication. After cleaning the affected area, apply an exact amount of cream to the wound. Apply it while wearing a medical glove. This is usually applied once or twice a day or as directed by your doctor. The wound should be covered with this medication at all times. If some of the cream rubs off the wound, re-apply it right away. Let your doctor know if your condition does not improve or if it gets worse. Do not suddenly stop using this prescription without the consent of your doctor.

What are the side effects of Mafenide Acetate?

• Redness, rash, itching, or blistering of treated skin
• Burning or pain of treated skin
• White or pruned appearance of treated skin
• Severe skin irritation
• Rapid breathing
• Dark colored urine
• Pale or yellowed skin

Warnings and Precautions

• Tell your doctor if you are allergic to this medication.
• Inform your doctor if you have any medical history or current medication.
• Do not share this or any of your prescriptions with others even if they have the same symptoms as yours.
• This medication may not be prescribed during pregnancy.
• Consult your doctor first if you are breastfeeding women.
• Keep this at room temperature away from heat or moisture.