Mononitrate

Where is Isosorbide Mononitrate used?

Isosorbide Mononitrate is a type of medicine known as nitrate used:

  • For the treatment of Heart failure
  • To prevent attacks of angina chest pain 

This medicine relaxes and widens blood vessels so blood can flow more easily to the heart. This is an FDA-approved prescription medication since 1991. 

How does Isosorbide Mononitrate work?

Isosorbide Mononitrate is a nitrate medicine that works by widening blood vessels both around the body and in the heart. 

  • Widening the veins decreases the capacity of blood that returns to the heart with each heartbeat, so makes it at ease for the heart to pump the blood out again. 
  • Widening the arteries around the body lowers the resistance that the heart has to pump against. 

These effects mean the heart does not need to use as much energy to pump the blood around the body and thus needs less oxygen.

By widening the arteries within the heart itself, this medicine also improves the oxygen and blood supply to the heart muscle. All of these actions allow the medicine to stop the painful angina attacks that happen when the heart does not get adequate oxygen for the work it is doing. Also, it helps manage heart failure where the pumping action of the heart has become less effective.

How is Isosorbide Mononitrate taken?

  • The dose of this medication that is prescribed to you and how often you need to take it depends on how well your condition is controlled. You must follow the instructions given by your doctor.
  • Your doctor may ask you to take a dose 1-3 times a day.
  • If you have been prescribed a long-acting or modified-release form of this drug, these are usually taken in the morning, once a day. 
  • This type of medicine should be swallowed as a whole with water/drink and not chewed or crushed.
  • Do not take this medicine to treat an attack of angina because it won’t work quickly enough. Follow the instructions given by your doctor. 

What are the possible side effects of Isosorbide Mononitrate?

  • Vomiting
  • Nausea
  • Dizziness
  • Headache 
  • Tingling under your skin
  • Skin warmth or redness
  • Hot flashes
  • Constipation

What are the precautions in taking Isosorbide Mononitrate?

  • Tell your doctor if you are allergic to this medication or similar drugs or if you have any other allergies. This product may contain inactive ingredients that can cause allergic reactions. 
  • Inform your doctor about any medical history you have. 
  • This drug may make you dizzy. Do not use machinery, drive, or do anything that needs alertness until you can do it safely. 
  • Older adults may be more sensitive to the side effects of this medication. This should be used with caution.
  • If you are using marijuana talk with your doctor. 
  • This medication should be used only when needed in pregnant women. 
  • Consult your doctor before breastfeeding. 
  • Keep a list of all the products you use including prescription and non-prescription drugs as well as herbal products. Share it with your doctor. Do not stop or change the dose of any medications without the approval of your doctor.