General Information

Nintedanib is used for the treatment of idiopathic pulmonary fibrosis (IPF). IPF is a type of chronic scarring lung disease. It is characterized by a progressive and irreversible decline in lung function. This disease scars and stiffens your lungs making it hard to breathe. Symptoms typically include gradual onset of shortness of breath and dry cough.

How does Nintedanib work?

Nintedanib inhibits tyrosine kinase. It is an enzyme essential for signal transduction pathways that trigger growth factors like:

• Vascular endothelial growth factor receptor (VEGFR)
• Fibroblast growth factor receptor (FGFR)
• Platelet derived growth factor receptor (PDGFR)

These are secreted in excess amounts in patients with IPF. This medication binds to the phosphorylating site of tyrosine kinase. That it blocks the cell signaling mechanism and slows the progression of the disease.

Why use Nintedanib?

Nintedanib is in the class of medications called kinase inhibitors. This drug may help slow down the worsening of your condition. Nintedanib is a bright yellow powder. This is supplied as a capsule for oral use. Each capsule contains Nintedanib as an active ingredient. This is available in the strengths of 100 mg and 150 mg. The Food and Drug Administration (FDA) has already approved this medication.

How to use Nintedanib?

Nintedanib is to be taken by mouth as directed. This is usually taken twice a day about 12 hours apart. Swallow the capsule as a whole with a full glass of water. Do not break or crush it. Remember to take it at the same time each day.

The recommended dosage is based on your medical condition and response to it. Use this regularly for the best benefit. This is to be taken exactly as it is prescribed. Let your doctor know if your condition does not improve.

What are the side effects of Nintedanib?

• Nausea
• Diarrhea
• Vomiting
• Stomach or abdominal pain
• Decreased appetite
• Headache
• Weight loss
• Hypertension

Warnings and Precautions

• Do not take more or less of this medication.
• Tell your doctor if you have any medical history or current medications.
• Before using, let your doctor know if you are allergic to this drug.
• You should not share this with others even if they have the same symptoms as yours.
• This medication is not recommended for use in pregnant women. If you are breastfeeding women, consult your doctor first before taking a dose.
• Let your doctor know if you ever had a heart disease or liver disease.
• Keep this drug at room temperature far from the heat and moisture.