Where is Niraparib used?

Niraparib is used as a maintenance treatment for recurrent fallopian tube, epithelial ovarian, or primary peritoneal cancer. This is usually used in patients who are in complete or partial response to platinum-based chemotherapy. This medication is usually started within 8 weeks following the most recent platinum-containing regimen. Niraparib is in the class of PARP inhibitors and is an FDA-approved prescription. 

How does Niraparib work?

Niraparib is a poly ADP-ribose polymerase (PARP) enzyme inhibitor. It is highly selective for PARP1 and PARP2. PARP1 and PARP2 are involved in detecting DNA damage and promote repair. Inhibiting PARP1and PARP2 enzymatic activity results in DNA damage, apoptosis, and cell death. This medication induces cytotoxicity in tumor cell lines with or without BRCA1/2 deficiencies. Wherein, it slows the growth of the cancer cells.

How is Niraparib taken?

This medication is taken by mouth at bedtime to lessen the risk of nausea and vomiting. Each dose of this drug may be taken with or without food. Swallow the medicine as a whole with a full glass of water. Do not change your dose or stop taking this unless your doctor tells you to do so. If you missed a dose, take your next dose at your usual scheduled time. Do not take an extra dose to make up for a missed dose. 

The dosage is based on your medical condition and response to the treatment. Your doctor may start giving a lower dose with this medication and gradually increase it. If you vomit after taking Niraparib do not take another dose just continue your regular dosing schedule. Be sure to tell your doctor about how you feel during your treatment with Niraparib. 

What are the precautions in taking Niraparib?

• High blood pressure is common during treatment with Niraparib and it can become serious. Your doctor will check your blood pressure and heart rate at least weekly for the first two months. Then, monthly for the first year and as needed thereafter during your treatment with Niraparib.
• Let your doctor know about all the medications you take including prescription and herbal supplements, over-the-counter medicines, or vitamins.
• If you have signs of an allergic reaction, call your doctor right away and stop taking Niraparib. Some signs of an allergic reaction may include hives, trouble breathing, or swelling of the lips, mouth, throat, or face. 
• Do not receive any kind of immunization or vaccination without the approval of your doctor while taking Niraparib.
• Inform your doctor if you are pregnant or may be pregnant before starting this treatment. Niraparib may be hazardous to the fetus.
• Do not breastfeed while taking Niraparib. If you are a breastfeeding women, inform your doctor before taking this prescription. 
• You may be at risk of infection so try to avoid crowds or people with colds, and report fever or any other signs of infection immediately to your health care provider.
• Drinking alcoholic beverages should be kept to a minimum or avoided completely. You should discuss this with your doctor.
• Get plenty of rest and maintain good nutrition. Remain active as you are able. Gentle exercise is encouraged such as a daily walk.