Exported Medicines

Perphenazine and Amitriptyline

Perphenazine and Amitriptyline

Perphenazine and Amitriptyline are indicated for the treatment of depression associated with anxiety. Depression and anxiety can occur at the same time. Some symptoms of these conditions overlap such as problems with sleep, irritability, and difficulty concentrating. But several key differences help distinguish between the two.

Physical symptoms and behavioral changes caused by depression include:

  • Chronic fatigue decreased energy, or feeling sluggish frequently
  • Difficulty making decisions, concentrating or recalling
  • Aches, pains, cramps, or gastrointestinal problems without any clear cause
  • Difficulty sleeping, waking early or oversleeping
  • Changes in appetite or weight

Emotional symptoms of depression include:

  • Persistent feelings of anxiety, sadness, or emptiness
  • Loss of interest or no longer finding pleasure in activities or hobbies
  • Irritability, anger, or restlessness
  • Feeling guilty or experiencing feelings of helplessness or worthlessness

Physical symptoms caused by anxiety disorder include:

  • Difficulty concentrating or recalling
  • Feeling fatigued easily
  • Racing heart
  • Muscle tension
  • Grinding teeth
  • Racing heart
  • Sleep difficulties including problems falling asleep and restless

Emotional symptoms of anxiety include:

  • Difficulty controlling worry or fear
  • Irritability, restlessness, or feeling on edge
  • Panic
  • Dread

Perphenazine and Amitriptyline is a combination of a tricyclic antidepressant and an antipsychotic medication. Together, they restore the balance of certain natural chemicals in the brain (norepinephrine, dopamine, and serotonin). This medication helps you to have a better mood and sense of well-being. This will also help you think more clearly and feel less nervous so that you can take part in your everyday life. The Food and Drug Administration (FDA) has already approved this medication.

Perphenazine and Amitriptyline is a product supplied as tablets for oral use. Each tablet has Perphenazine and Amitriptyline as an active ingredient. This is available in the dosage strengths of 10 mg/2 mg, 25 mg/2 mg, 10 mg/4 mg, 25 mg/4 mg, and 50 mg/4 mg.

How do Perphenazine and Amitriptyline work?

This type of medications acts on the nerve cells in the brain. In the brain, there are numerous different chemical compounds called neurotransmitters. These act as chemical messengers between the nerve cells. Noradrenaline and serotonin are neurotransmitters and they have various functions that we know of. When noradrenaline and serotonin are released from nerve cells in the brain they act to lighten the mood. When they are reabsorbed into the nerve cells, they no longer affect mood. It is thought that when depression occurs, there may be a reduced amount of noradrenaline and serotonin released from nerve cells in the brain.

Amitriptyline works by preventing noradrenaline and serotonin from being reabsorbed back into the nerve cells in the brain. This helps prolong the mood lightening effect of any released noradrenaline and serotonin. In this way, Amitriptyline helps relieve depression.

Perphenazine also acts in the brain, where it blocks dopamine receptors. Dopamine is another neurotransmitter that is involved in regulating mood and behavior. Blocking its activity produces a calming effect and helps control delusions and anxiety.

How to use Perphenazine and Amitriptyline?

The dosage will depend on your medical condition, age, weight, and response to the treatment. Your doctor may direct you to start at a low dose and gradually increase it. Follow the instructions of your doctor very carefully. You should not take the medication more or less than it is prescribed.

This medication is to be taken by mouth usually 1 to 4 times a day or as directed by your doctor. You may take each dose with or without a meal. The tablet is to be swallowed as a whole with a full glass of water. If you take it only once a day, take it at bedtime to help lessen daytime sleepiness. Do not break, chew, or crush it. Use Perphenazine and Amitriptyline regularly for the best benefit. To help you remember, take it at the same time each day. Let your doctor know if your condition does not improve or if it gets worse.

What are the side effects of Perphenazine and Amitriptyline?

Common side effects:

  • Restlessness and agitation
  • Drowsiness
  • Abnormal movements of the legs, hands, neck, face, and tongue
  • Increased salivation or dry mouth
  • Blurred vision
  • Constipation
  • Nausea
  • Difficulty passing urine
  • A drop on blood pressure that may cause dizziness
  • Skin reactions such as rashes, sweating, and sensitivity to sunlight
  • Headache
  • Difficulty sleeping or insomnia
  • Confusion
  • Increased appetite and weight gain
  • Taste disturbances
  • Faster than normal heartbeat
  • Disturbances in the normal numbers of blood cells in the blood

Warnings and Precautions

  • This is not recommended for use during pregnancy unless it is given by your doctor. If you get pregnant while having this medication, call your doctor and stop taking this drug.
  • Perphenazine and Amitriptyline may cause drowsiness and blurred vision. If affected do not drive or use any machinery.
  • You should avoid drinking alcohol while having this medication. It may make you drowsier.
  • Do not suddenly stop taking Perphenazine and Amitriptyline without the consent of your doctor. Your condition may become worse when stopped.
  • Use this carefully in elderly people and young people under 25 years of age.
  • If you are breastfeeding women, consult your doctor first.
  • Do not share this medication with others even if they have the same symptoms as yours.
  • If you missed a dose, take it as soon as you remember it. If it’s almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take twice the prescribed dosage to make up for the missed dose.
  • Keep Perphenazine and Amitriptyline at room temperature.

This medication should be used with caution in people:

  • With a history of suicidal behavior or thoughts
  • With a history of bipolar affective disorder
  • With a decreased liver function and heart disease
  • Receiving electroconvulsive therapy
  • With Parkinson’s disease and an overactive or underactive thyroid gland
  • With a personal or family history of raised pressure in the eye or closed-angle glaucoma

This medication should not be used in people with:

  • Glaucoma
  • Epilepsy
  • An irregular heartbeat
  • A recent heart attack
  • Low numbers of white blood cells in their blood
  • A manic phase of bipolar affective disorder
  • Severely decreased liver function