Pregabalin

Where is Pregabalin used?

Pregabalin is used for the treatment of epilepsy, generalized anxiety disorder, and neuropathic pain such as diabetic neuropathy that occurs after having shingles.

This is an anticonvulsant medicine that can be used in combination with other medications to treat the illness. This is supplied as capsules for oral use.  

How does Pregabalin work?

Pregabalin binds to calcium channels found on nerve cells in the spinal cord and brain. This reduces the release of several neurotransmitters from these nerve cells. Neurotransmitters are involved in spreading messages between the nerve cells. This medicine decreases the release of noradrenaline, glutamate, and substance P. Glutamate is out once electrical signals accumulate in nerve cells and then excites more nerve cells. It is believed to play an important role in triggering epileptic seizures.  

Decreasing the release of glutamate from the nerve cells in the brain is thought to help stabilize the electrical activity in the brain and prevent epileptic fits. Noradrenaline, glutamate, and substance P are also involved in transmitting pain signals in the brain and nervous system. As Pregabalin decreases the release of these neurotransmitters, it can similarly use in nerve pain occurring because of nerve damage, or a disruption in the role of nerves.

How is Pregabalin taken?

Pregabalin is to be taken by mouth as directed by your doctor. The medicine is usually taken once a day after an evening meal. The recommended dosage is based on your medical condition and response to the treatment.

Do not suddenly stop taking Pregabalin without the consent of your doctor. Even if you feel well, continue to take the medication until the full prescription is done. To help you remember, take the drug at the same time and in the same way each day. Drink plenty of fluids while having this treatment. Doing so may lessen the risk of certain side effects.

What are the possible side effects of Pregabalin?

Common side effects:

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Edema
  • Sleepiness
  • Constipation
  • Blurred vision

Call your doctor right away if you have:

  • Skin sores
  • Swelling in your hands or feet
  • Vision problems
  • Unexplained muscle pain, weakness, or tenderness
  • Rapid weight gain especially if you have heart problems or diabetes
  • Easy bruising or unusual bleeding

What are the precautions in taking Pregabalin?

  • Before having Pregabalin, tell your doctor if you have any medical history especially of kidney disease, heart problems, or overuse/addiction to drugs or alcohol.
  • This medication may make you dizzy. Do not do anything that needs your alertness until you know how this drug affects you.
  • While having this medication, avoid alcoholic beverages. It may increase your risk of having some side effects.
  • This is not recommended for use in pregnant and breastfeeding women.
  • Do not give this medicine to a child without medical advice. Pregabalin is not approved for seizures in anyone younger than 4 years old.
  • This medication can decrease sperm count and may affect fertility in men. Ask your doctor about the risk and benefits of this drug before using.
  • This should not be used for the treatment of other conditions.