Exported Medicines

Subutex (Buprenorphine) Sublingual Tablets

Subutex (Buprenorphine) Sublingual Tablets

General Information

Subutex (Buprenorphine) is used to treat dependence or addiction to opioids (narcotics). This is also prescribed in lower dosages to treat pain and dependence on opioid painkillers like oxycodone (OxyContin).


How do Subutex (Buprenorphine) Tablets work?

Subutex (Buprenorphine) pain-relieving effect is due to partial agonist movement at mu-opioid receptors. This is also a kappa-opioid receptor antagonist. The partial agonist activity means that opioid receptor antagonists only partially reverse the effects of buprenorphine. The binding to the mu and kappa receptors results in reduced neuronal excitability and hyperpolarization. In addition, it slowly dissociates from its receptor. This reflection would account for the longer duration of action compared to morphine. And the unpredictability of its reversal by opioid antagonists and its low level of manifest physical dependence. Its receptor fixation half-life is 40 minutes which is significantly longer than morphine.


Why use Subutex (Buprenorphine) Tablets?

Subutex Tablets contain the active ingredient of Buprenorphine as the hydrochloride. It belongs to the class of drugs called mixed opioid agonist-antagonists. This is available in two dosage strengths; 2mg and 8mg of Buprenorphine. The Food and Drug Administration (FDA) has approved this treatment.


How to use Subutex (Buprenorphine) Tablets?

The dosage is based on your medical condition and response to the treatment. This is usually taken once a day. Place Subutex Tablets under your tongue for 5-10 minutes and let it dissolve completely. If you are prescribed more than one tablet each day, you may place it all under your tongue at once. You may also place two tablets under your tongue at a time. Do not chew or swallow this medication. Take this regularly or as directed by your doctor. To avoid some complications, do not double the given dosage.


What are the side-effects of Subutex (Buprenorphine) Tablets?

  • Constipation
  • Stomach pain
  • Headache
  • Vomiting
  • Sweating
  • Difficulty falling asleep or staying asleep
  • Dizziness
  • Spinning sensation
  • Numbness or tingly feeling
  • Blurred or double vision
  • Hives
  • Skin rash
  • Loss of appetite
  • Lack of energy
  • Confusion
  • Difficulty breathing or swallowing


Warnings and Precautions

  • Before taking Subutex Tablets, let your doctor know if you have any allergies, medical history, or current medications.
  • Consult a doctor if you are pregnant or breastfeeding women.
  • Do not use this longer than prescribed.
  • You should not share this with others who have the same symptoms as yours.
  • If some side effects persist or get worse, call for medical help right away.
  • Keep this away from moisture, heat, and reach of children.