Tinzaparin Sodium

Where it is used and how does it work?

Tinzaparin sodium is used for the treatment of certain blood clots such as deep vein thrombosis and pulmonary embolism. This may also be used to prevent the formation of blood clots in people who had surgery and prevent blood from clotting when it is filtered through an artificial kidney machine. Wherein, it is as part of the management of kidney failure. 

Blood clots usually only form to stop bleeding that has occurred as a result of injury to the tissues. The clotting process is complicated and begins when blood cells called platelets clump together. It produces chemicals that activate the clotting process. The final part of this process involves a substance called thrombin being activated to produce a protein called fibrin. Fibrin binds the platelets together and forms a blood clot. This is the body’s natural way of repairing itself. Sometimes, a blood clot can form unusually within the blood vessels. This is known as a thrombus. It can be dangerous because the clot may detach and travel in the bloodstream. Wherein, it becomes known as an embolus. The embolus may eventually get lodged in a blood vessel. Thereby, it blocks the blood supply to a vital organ such as the heart, brain or lungs. This is known as a thromboembolism. 

Some people have an increased tendency for blood clots to form within the blood vessels. This is usually due to a disturbance in the blood flow within the blood vessels. For example, slow blood flow in the leg and pelvic veins can result in clots forming in these veins. These clots can break off and travel to the lungs. 

Tinzaparin is used to prevent and treat these types of abnormal blood clots. It works by inactivating thrombin in the clotting process described above. This stops the formation of fibrin which is the essential component of blood clots.

Deep vein thrombosis happens when a blood clot forms in one or more of the deep veins in your body. This can develop if you have certain medical conditions that affect how your blood clots. Deep vein thrombosis signs and symptoms can include:

  • A feeling of warmth in the affected leg
  • Red or discolored skin on the leg
  • Pain in your leg which often starts in your calf and can feel like cramping or soreness

Pulmonary embolism is caused by blood clots that travel to the lungs from deep veins in the legs. This condition is a blockage in one of the pulmonary arteries in your lungs. The clots block blood flow to the lungs. Taking measures to prevent blood clots in your legs will help protect you against pulmonary embolism. Common signs and symptoms may include:

  • Cough which may produce bloody or blood-streaked sputum
  • Chest pain that feels like having a heart attack. The pain is often sharp and often stopping you from being able to take a deep breath. 
  • Shortness of breath that may typically appears suddenly ad always gets worse with exertion 

Tinzaparin Sodium is known as a blood thinner or anticoagulant. This is a type of medicine called low-molecular-weight heparin. Tinzaparin Sodium blocks certain natural substances in the blood that cause clotting. The Food and Drug Administration (FDA) has already approved this prescription. 

How to use Tinzaparin Sodium?

This medication is to be injected under the skin of the stomach or abdomen usually once a day as directed by your doctor. Do not inject into a muscle. The dosage is based on your medical condition and response to the treatment. Use this regularly and at the same time each day to get the most benefit from it. 

Check this product visually for particles or discoloration before using it. If either is present, do not use the liquid. Do not mix any other medication in the same injection. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen the injury under the skin. Do not rub the injection site after a shot to minimize bruising. Learn how to keep and discard medical supplies safely. Let your doctor know if your condition does not improve or if it gets worse. 

What are the side effects of Tinzaparin Sodium?

Common side effects:

  • Sleep problems or insomnia 
  • Skin rash 
  • Constipation
  • Diarrhea
  • Gas
  • Stomach pain
  • Vomiting
  • Nausea
  • Fever
  • Nosebleed 
  • Back pain
  • Dizziness
  • Headache
  • Injection site reactions (bruising, pain, irritation, redness, or swelling)

Let your doctor know if you have these side effects:

  • Yellowing eyes or skin
  • Dark urine
  • Easy bleeding or bruising 
  • Persistent vomiting, nausea, or loss of appetite

Get emergency medical help if you have signs and symptoms of an allergic reaction:

  • Hives or itching
  • Trouble or difficulty breathing 
  • Swelling of throat, lips, mouth, or face 

If these side effects persist or get worse, call your doctor right away. 

Warnings and Precautions 

  • Your doctor may also want to monitor the level of potassium in your blood while you are having this medicine, particularly if the treatment lasts for longer than seven days.
  • If you are having this medicine for longer than four days you should have a regular blood test. 
  • You should tell your doctor if you experience signs of a potential problem which include weakness, tingling, or numbness in your lower legs, back pain or problems in going to the toilet. People who are having this medicine to treat a blood clot should not be given spinal or epidural anesthesia.
  • Tinzaparin sodium should be used with caution in people with an increased risk of bleeding complications, decreased kidney function, and decreased liver function, diabetes, and an increase in the acidity of the blood.
  • In people with a high level of potassium in the blood and people taking potassium-sparing diuretics, this medicine should also be used carefully.
  • This is not recommended in people with a low number of platelets in the blood, with an increased risk of serious bleeding, recent brain hemorrhage, and recent injury or surgery to the brain or spinal cord, ears, or eyes. 
  • If you are pregnant or breastfeeding women, consult your doctor first before using this drug.