Trospium Chloride

Where is Trospium Chloride used?

Trospium Chloride an FDA-approved medication used for the treatment of overactive bladder. This is in the class of medication called antispasmodics. By calming the muscles in the bladder, it develops your capability to regulate your urination. It helps to lessen your frequent trips to the bathroom, leaking of urine, and feelings of needing to urinate right away.

How does Trospium Chloride work?

Trospium Chloride is a type of drug called an antimuscarinic muscle relaxant. It relaxes the involuntary muscle that is found in the wall of the bladder. The muscle in the wall of the bladder is called the detrusor muscle. At times it might contract in strong spasms. This is frequently stated as having an overactive bladder. The overactive detrusor muscle can increase in the times you cause uncontrollable urges to pass urine or you need to pass urine. It may as well be an involuntary leakage of urine. 

This medicine relaxes the detrusor muscle in the wall of the bladder by blocking muscarinic receptors that are found on the surface of the muscle cells. This inhibits acetylcholine which is an ordinary body chemical from acting on these receptors. Usually, when acetylcholine acts on these receptors, it causes the detrusor muscle to contract and the bladder to empty. By blocking acetylcholine, this drug helps the muscle in the bladder wall to relax. This decreases unbalanced and involuntary contractions of the bladder. Thereby, it increases the capacity of the bladder to hold urine. In turn, this lessens the need to pass urine.

How is Trospium Chloride taken?

This is to be taken usually twice a day by mouth. Each dose is taken on an empty stomach or 1 hour before meals. It is sometimes taken once a day at bedtime. The dosage will depend on your medical condition and response to the treatment. Avoid drinking alcohol or taking any product that contains alcohol for 2 hours before and after taking this drug. Alcohol can destroy the long action of the drug and may increase side effects.

To get the most benefit from it, use this medication regularly. You should not take more or less or take it more often than it is given by your doctor.

What are the precautions in taking Trospium Chloride?

  • Tell your doctor if you have any allergies. If there are any signs and symptoms of allergies, call your doctor right away. 
  • Before using this drug, tell your doctor if you have any medical history especially of liver or kidney disease, glaucoma, inability to urinate, or intestinal/stomach problems. 
  • This medication may make you dizzy or drowsy. Do not use any machinery or perform any activity that needs your alertness. 
  • Your doctor should reassess whether you still need treatment with this drug every 3-6 months. 
  • Trospium Chloride is not recommended for use in children under 12 years old. 

This medication should be used with caution in people with:

  • Obstruction of the outflow of urine from the bladder.
  • Obstruction or decreased motility of the stomach or intestines, such as pyloric stenosis.
  • Disorder of the involuntary nerves that control the internal organs
  • Heart disease
  • Hiatus hernia 
  • Overactive thyroid gland

This medication is not recommended for use in people with:

  • Abnormal muscle weakness
  • Closed-angle glaucoma
  • Severe inflammation of the bowel and back passage
  • Fast or abnormal heart rhythms
  • Rare hereditary problems of galactose intolerance